![]() ![]() ![]() ![]() So while the number of holidays observed is always the same, the university may have a different schedule than state agencies. However, institutions of higher education are allowed to be flexible when establishing their own schedules. The university observes the same number of holidays, a combination of national and state holidays, that are observed by state agencies. The state legislature determines the number of holidays that can be observed by all state agencies and institutions of higher education. The holiday schedule is published each year. For more information, please see the university's Handbook of Operating Procedures. If your position requires you to have student status as a condition of employment, you aren't eligible for paid holiday time off. If you're appointed less than full-time, you'll be granted holiday leave based on the percentage of hours you're appointed. If you're faculty, you must be appointed for at least 50% time for at least 4.5 continuous months. You receive paid holiday time off when you're appointed to work at least 20 hours per week for at least 4.5 continuous months. Holidays | Human Resources retweet icon bullhorn icon reply icon info icon flickr icon tumblr icon vimeo icon reddit icon podcast icon angle-down icon angle-left icon angle-right icon angle-up icon ban icon hamburger icon book icon bookmark icon bug icon caret-down icon caret-left icon caret-right icon caret-up icon chain icon check icon check-circle icon chevron-down icon chevron-left icon chevron-right icon chevron-up icon circle icon circle-o icon clone icon close icon download-cloud icon code icon download icon ellipsis icon envelope icon warning icon external-link icon eye icon eye-slash icon facebook icon github icon google-plus icon heart icon heart-o icon home icon info-circle icon instagram icon linkedin icon lock icon medium icon minus-circle icon send icon pause-circle icon play-circle icon plus-circle icon question-circle icon quote-left icon quote-right icon rss-square icon search icon share-alt icon slack icon snapchat icon ticket icon twitter icon wheelchair icon youtube icon ![]()
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![]() ![]() RPS: So is the process of creating the game therapeutic? Has it helped exorcise anything for you? Beautiful things has also happened on the way, and those happy event are those who really helped to battle my mental state. So yes, Fran Bow is a gathering of many events that have being crucial in my life and in a way, I don't want to speak only for myself, but also the others I meet on my way, because not everything is about painful situations. There is something else, that I want to keep to myself, but that event is the one that actually detonated everything inside my mind. And as a teenager being sentenced to be part of a religious sect, being kind of a guinea pig for research with all medicines doctors gave me to try to cure the mental illness that life was giving me. From childhood I have being experiencing traumatic events, from being witness to family violence to unfair personal treatment outside home. Natalia Figueroa: The game itself is a kind of screaming out what I been experienced through my childhood and teenager years. Can you talk a bit about that, whatever you're comfortable with sharing? Then I hear you say that it's based on your own life. And it's all approached with such a cold, sterile response. A girl watching her parents slaughtered in front of her, who maybe goes mad, goes into an asylum, and then with medication sees mutilated corpses of children, desecrated animals, terrible demons and all sorts of bloodshed. It was more disturbing than I was comfortable with. And I'll be honest - I found it incredibly disturbing. So it should be said up front that this interview touches on subjects of sexual and physical abuse, alongside the impact such a project might have, and indeed what else to expect in the game. And then I saw that one of the co-creators, Natalia Figueroa, mentioned that it was semi-autobiographical. It was too much for me - I found it very unnerving. The demo, set in an asylum, shows the morbid, hideous version of reality perceived by this girl - a world of brutal death, mutilated children, and dismal hopelessness. A tale of a 10 year old girl who witnesses the brutal murder of her parents, and then seemingly develops severe mental health issues. But as Ben found when he played it, and I certainly did too, this is something incredibly disturbing. A point and click adventure with an ongoing IndieGoGo campaign, and an available demo. Continued abuse of our services will cause your IP address to be blocked indefinitely.You may have seen our mentioning Fran Bow earlier this month. Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. 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The latest version of the Opera browser sends multiple invalid requests to our servers for every page you visit.The most common causes of this issue are: Your IP address has been temporarily blocked due to a large number of HTTP requests. ![]() ![]() ![]() Normal epithelial cells proliferate better under aerobic conditions, making it impractical to distinguish the effects of drugs on patient tumor and normal cells.īased on the conventional CR system, to guide the individualization of therapy, here we report a modified individual CR system (termed i-CR), characterized by selective expansion of tumor cells from CRC patients in vitro. ![]() A limitation of CR technology is its inability to distinguish between tumor and normal epithelial cells, as both proliferate well in the system. Thus, CR technology may guide the individualization of cancer treatment. The CR system can be used to expand normal and tumor cells from different tissues, including surgical specimens, biopsies, and PDX tissues. Recently, a novel primary cell culture technology, conditional reprogramming (CR), was reported by Liu and coworkers and allows expansion of primary epithelial cells in vitro with high efficiency. We established a primary tumor bank with various tissue types, including colorectal (CRC) and gastric cancers, but the cost and duration of the experiments and low throughput of the PDX models hindered achievement of treatment goals, especially for late-stage disease. Compared to conventional primary cell culture, PDX models and organoids can mimic patient genotypes, maintain intra-tumor heterogeneity, and evaluate the response to cancer therapies. Patient-derived xenograft (PDX) models and organoids are suitable surrogates for original tumors. Functional drug testing by traditional primary cell culture of patient tumor tissue is subject to the proliferation bias of different cell clones, which can lead to inaccurate results. To achieve individualized cancer therapy, novel preclinical models that more closely reflect the genomic complexity of cancers are needed. The novel i-CR system combined with PDX models will enable individualization of therapy and drug discovery, and strategies combining EGFR, MEK, and CDK4/6 inhibitors warrant clinical validation. These data were validated using paired PDX models, which showed marked inhibition of tumor growth. Using inhibitors targeting multiple signaling pathways identified by high-throughput i-CR drug screening, we discovered that inhibition of the EGFR and MEK or CDK4/6 pathways exerted a synergistic inhibitory effect against CRC, and we noted super-synergistic effects when EGFR, MEK, and CDK4/6 inhibitors were used simultaneously. The i-CR system selectively expanded tumor cells rather than normal epithelial cells and facilitated high-throughput drug screening when combined with high-content imaging and quantitative analysis of cell proliferation. Tumor samples from CRC patients were collected and PDX models were derived followed by high-throughput i-CR drug screening and validation of the effective targeted drug combinations. ![]() By modifying the ingredients of the culture medium used in a conventional CR system, a novel individualized CR system (termed i-CR) was established. We explored the optimum preclinical model by modifying the conventional conditional reprogramming (CR) system followed by screening effective targeted drug combinations against colorectal cancer (CRC). ![]() Preclinical models, including patient-derived xenograft (PDX) and organoid and primary cell culture, are essential for studies of cancer cell biology and facilitate translational research and individualization of therapy. ![]() ![]() These characters will often talk about how out of touch they are and complain about various events and items around the island, making them fun in short doses but a buzzkill in large ones. One Cranky-type villager like Apollo can add a much-needed amount of zest to daily interactions, but get too many of them on one island and it’ll start to get annoying. Whether weight training or running around town, putting these villagers together in an Animal Crossing island is a recipe for disaster. However, jocks in particular don’t often seem to talk about others without mentioning themselves. Aside from the New Horizons villagers chastising players for being away, many of the personality types get along fine with the player character and other community members. Putting all of these villagers into a town together means that they’ll often just be talking about personal betterment. Many players consider Moose, Louie, and Coach some of the worst offenders for being pushy as well as hard on the eyes. It’s a strangely specific interest in a world full of cranky and peppy alternatives, with villagers specifically calling out their glutes and biceps. Being inundated with talk of muscles not only wears on players fast, it’s also a tad intrusive and strange. These characters have gained a reputation for only talking about fitness and not actually doing any fitness themselves. Of course, at the top for worst Animal Crossing combinations is an island full of Jock-type villagers. Contrasted with the Animal Crossing villagers with the most interesting personalities, below are some of the worst villager personality types to have coagulated in one village, as well as the worst offenders to combine together. Some may be fine on their own, but often, having everyone talk the same will make the island sound like a suburban nightmare. Variety is the spice of life, and so if a player were to fill their entire New Horizons island with one type of villager, it would become grating very quickly. Related: Animal Crossing Dab: Cooking, Fishing, & Real-Life Facts People who want to invest a lot of time into the game will want to make sure to include all sorts of personalities, as interacting with villagers daily gives players rewards and Nook Miles for their trouble. ![]() Villagers of the same type pull from the same possible conversations, meaning that an ideal village would have a lot of different types to mix up dialogue options. Each villager has one of nine possible personalities in New Horizons tied to gender, ranging from lazy to peppy. ![]() ![]() The better product you choose as the main one, the higher the chances that your clients will buy this bundle. This way, marketers give their new products a boost and promote them for free. This type implies offering a recently launched item together with a high-selling product. For example, customers are always offered to buy a case or earphones together with a phone. It means offering a product that complements the initial choice, and this complimentary product often can’t be used separately. For these packages, companies often use perishables, for example, toiletries, six-packs of fresh juice or beer, and an option to choose a T-shirt when buying a pair of jeans at $X. This makes them feel as if they have full control of the transaction. This bundling technique enables marketers to choose several products available for packaging so that clients can choose the necessary items and create a custom bundle. For example, cable TV providers offer packages with channels that cannot be sold individually bus tour providers offer their clients tours that include a transfer, hotel accommodation, a guided walking tour, and headphones. This type of bundling is often used by monopolies that aim to limit their clients’ choices. It implies a mix of products that can be bought only within a bundle, and no item is sold separately. In this section, we’ll shed some light on eight types of product bundling so that you can discover the opportunities they bring. Now that you know why companies bundle products and the benefits they reap, it’s time to get familiar with the types of product bundling to choose one that works best for your business. Remember that customers will appreciate your care and attention. You can offer them chemical peels and a moisturizer to cope with this problem effectively. For example, your client always buys a skin whitening cleansing foam, so we can assume they have acne marks. Then, create a relevant product mix based on their needs. Check out the profiles of your regular customers in your CRM to explore their favorite products. ![]() You can increase customer retention and loyalty by providing them with unique and personalized offers. Besides, you’ll save money on packaging since you need only one box to send a set of products. Hence, if you have five best-selling products, try bundling them with your slowly-moving inventory and sell them at a reduced price. If marketers advertised each product of their company, the revenue would not cover these costs since there are always some goods that do not sell well. Each product needs promotion, and promotion needs investments. Saving money on promotion and distribution.The only thing you need is to combine them wisely. You can make room by bundling these items with the most selling products that will work perfectly together. Such items stagnate on shelves, hindering new arrivals. Each company has some dead stock in its warehouses. This method will help you significantly increase the sales volume and enable clients to explore your new products. Some of your products that don’t sell can lack promotion, so combining them in a bundle with the most-selling products would be a good idea. Calculating this metric will help you identify the most effective selling techniques and determine high-performing sales reps. This measure shows both your general business health and the performance of your marketing campaigns in particular. ![]() Sales volume is the number of products sold during a particular period, for example, a quarter. Remember to choose products that complement each other and work effectively in combination. If you aim to increase your order value, consider offering your customer to buy a skincare set consisting of your best-selling foam, a slow-moving toner, and a cream for $35 only. Your top-selling product is facial cleansing foam. Say, you own a beauty store, and your average order value is $15. Let’s discover the benefits a business can reap after creating a well-thought-out product bundling strategy. Saving money on promotion and distribution. ![]() Let’s discover these benefits in more detail. This technique can increase your company’s average order value, sales, and revenue, save money on promoting and distributing individual products, and enhance customer experience. Customers buy these sets because they help them save money and try new products at low risk since brands usually combine top-selling products with low-selling items. Nowadays, almost every brand offers its clients a package, a combo, or a mix based on their needs and preferences. Such product bundles are useful for both customers and brands. With this strategy, McDonald’s sells its Happy Meals beauty stores create packages including shampoos, conditioners, and hair masks hotels offer rooms with breakfast included. ![]() This technique is popular among eCommerce businesses, fast food restaurants, the hotel industry, etc. ![]() ![]() ![]() It simply does not have the agency or capability to do anything but provide derivative responses in the face of human-initiated prompts.įor these reasons and so many more, ChatGPT does not represent any meaningful replacement for writers, educators or human professionals in general. Most fundamentally, ChatGPT cannot actually ask questions of its own at all. Indeed, ChatGPT cannot engage a learner in a two-way dialogue - considering their state of mind and developmental needs - in order to provide personalized feedback and help them understand a new concept. Notably, ChatGPT cannot facilitate higher-order conceptual learning. In this context, learning denotes higher-order cognitive development beyond simple memorization of facts or information it requires the development of conceptual understanding alongside an ability to analyze and evaluate the meaning and significance of the topic at hand. Here again, it is important to qualify what we mean by learning. Similarly, the science of human learning has shown us that students learn not only through their abilities of reasoning, interpretation and creative expression - which ChatGPT lacks - but also with the help of teachers who engage them in a two-way dialogue accompanied by feedback that is adjusted to their understanding and overall needs. ![]() Today, audio recording technology is an important tool for journalists but one wielded in service to its human users. What this suggestion failed to recognize is that journalists don’t simply record what someone says they interpret it and, most importantly, ask questions to understand or even challenge what they are hearing. When audio recording technology became commonplace in newsgathering during the 20th century, some suggested that it would replace many journalists who would otherwise attend news conferences and other newsworthy events. This is the first and most fundamental reason that ChatGPT cannot ever truly replace professional writers - whether they be journalists, novelists or academics. While ChatGPT can respond to creative inquiries and even some metaphorical prompts with seemingly meaningful replies, it is important to remember that it is simply reconstituting existing language without any thought, free creation or metaphorical meaning of its own. Telling someone that you are “trying to keep your head above water” at work is nonsensical when interpreted literally, yet extremely meaningful to a human mind that can understand the shared conceptual relationships between overwhelming workload and the struggle to not drown. While poetry and literary metaphor are one part of this, everyday metaphor is a much larger phenomenon that allows us to communicate beyond the literal. Second, this phrase also reminds us that a large amount of natural human language is symbolic and metaphorical. ![]() ![]() ![]() If the ground freezes before the plants mature, mulch them with hay and leave them be until the temperatures warm again in spring. In warmer climates, you could quite possibly be harvesting well into winter. You can continue sowing spinach seeds late into the fall season. You can continue to succession plant until February. I have found this is the only time I can grow spinach here in Florida. Start seeds in September and plant out direct seed in October. Spinach also grows well in the cool, short days of fall. You can extend the season slightly by planting in the shade of taller plants and keeping your spinach plants regularly watered. Expect to stop sowing spinach seeds sometime in May or June, depending on your climate (not in Florida). Of course, you can eat your thinnings.Īs the weather warms, spinach plants will bolt more quickly. Once the plants have a grown their true leaves, you can begin to thin the plants to about 6″ apart. Cover lightly with soil, firm in place and water well. apart or simply scatter the seeds in blocks. Sow the spinach seeds thinly in rows spaced about 1 -1 ½ ft. Spinach also matures and goes to seed quickly, so it is better to re-seed every couple of weeks than to try and plant a large crop to harvest over time. Spinach grows quite quickly, so don’t start plants indoors more than a 2-3 weeks before you plant to transplant them out. You can start spinach indoors or direct seeded in the garden as soon as the soil is workable. Fish emulsion and soy meal are good organic choices. A fertilizer high in nitrogen, the first number on the fertilizer package, will help produce dark, healthy leaves. Because it is such a fast grower, it is also a heavy feeder. ![]() Spinach prefers a well draining soil with a neutral pH and won’t be happy in a pH lower than 6.0. ![]() ![]() ![]() Wondershare UniConverter lets you convert them to high-quality files specifically optimized for playback on your favorite devices: iPad, iPhone, Android, Xbox, PlayStation Vita, Nexus, Kindle Fire, and many more smartphones, game systems, and tablets. This means you can store your UHD on your devices at half the normal file size! A Flawless DVD Experience – Anywhere High Efficiency Video Codec (HEVC) is the successor to the H.264 compression standard and offers twice the compression while still maintaining the same high quality. Let’s go wireless! Enjoy High Fidelity HEVC/H.265 Video No need for an external hard drive or a USB cable. All video and audio formats are supported. As long as your PC and smart TV or media streamer are connected to the same network, Wondershare’s Media Server plugin will work for you. In one click, Wondershare UniConverter, streams your media files on a PC to a smart TV directly or to a standard TV via media streamers like Chromecast (Roku, Apple TV, Xbox 360 or PS3). Streaming Your Media to TV Couldn’t Be Easier Screen Recorder – Record all desktop activities with voice.Cast Video to TV – Cast videos to TV as a media server.GIF Maker – Convert a video or photos to a GIF picture.DVD Copy (Only for Mac) – Copy DVD to ISO or DVD folder directly.VR Converter – Convert any video to VR format.Fix Video Metadata – Fix metadata info for videos.Wondershare UniConverter also is All-Purpose Video Toolbox. Wondershare UniConverter is surprisingly easy and amusing for family media enjoyment, by allowing you to merge multiple files into one file, to clone a file, to clip one file into multiple segments, to trim the file length, to crop video, to adjust video effect, to edit either text or image watermark, to add subtitle, to set video and audio output settings, to capture images from video/DVD files, to customize DVD menu and so on. ![]() Enjoy a movie theater experience in your home! Wondershare’s fully-featured player supports all major formats, even HD videos and DVDs. Enjoy the latest addition to the VCU in the new 4K Ultra HD video format! With 4K, enjoy the absolute best and finest picture quality today! New formats are constantly added making the Wondershare UniConverter the most user friendly video converter on the market. Convert home movies to any video/audio, for playback on any devices. Download or record videos from YouTube, Google, Yahoo and other video-sharing sites. 159 formats supported and counting! BUY NOW Wondershare UniConverter – 20% OFFīurn video files to Blu-Ray, DVD disc, DVD folder, or ISO files. Even convert video to 3D and 4K Ultra HD video format at ultrafast speeds. Wondershare UniConverter (originally Wondershare Video Converter Ultimate) will make your movies versatile by instantly converting them to AVI, WMV, MP4, MKV, FLV, 3GP, MPG. Convert videos to and from virtually any video format out there, with 30X faster conversion speed. Wondershare UniConverter is a complete video toolbox that lets you convert, edit, enhance, download, burn, organize, capture and watch video files. ![]() ![]() ![]() Press Windows + E key combination to open Explorer, then enter Control Panel in the address bar and press Enter. Launch Control Panel with Command Promptįirst, open the Command Prompt then enter the Control command into the Command Prompt window to open the Control Panel. To run a Control Panel tool in Windows, type the appropriate command in the Open box or at a command prompt. ![]() ![]() Press Windows + R key combination to open the Run dialog box, then enter the command shell: ControlPanelFolder or enter Control into the Run dialog window and press Enter. Launch Control Panel on the Run dialog box On Windows Server 2012 Desktop, hover over the upper right corner of the screen, then click Setting and then click Control Panel. On the Start Screen you will see Control Panel, click on it to open the Control Panel. Or alternatively, hover your mouse on the lower left corner of the Desktop, click Start. This will open Programs and Features as Administrator/Other user. runas /username:computernameAdministrator 'rundll32.exe shell32.dll,ControlRunDLL appwiz.cpl '. Pittsburgh Computer Solutions is an IT service provider. Press Windows + C key combination then click Start to open Start Screen. You need to hold down the SHIFT key while right-clicking in Win7. Hold down the Ctrl key and select each network connection that you want to add to the bridge. In the search box, type adapter, and then, under Network and Sharing Center, click View network connections. That will upgrade the Standard User account to Administrator. 1.Open Network Connections by clicking the Start button, and then clicking Control Panel. From the ''Change Account Type' window, use the dropdown for the 'Account Type' to pick 'Administrator.' Press the 'OK' button when you're done. On the screen, press the Windows + X key combination and select the Control Panel option to open the Control Panel. Select 'Yes' when the User Account Control prompt asks you whether you want to let the 'Settings' app make changes. In the article below, Network Administrator will show you 6 ways to access Control Panel on Windows Server 2012. Unlike other Windows versions, Windows Server 2012 interface has some new features so when you access applications, installing on Windows Server 2012 will be different than previous Windows versions. Windows provides a range of tools on the Control Panel so users can easily customize most settings. ![]() ![]() Recover several types of data with preview, including contacts, messages, photos, video, and also from iCloud. Free Lifetime upgrades in the Professional Edition.ĮaseUS MobiSaver hassle-free iPhone recovery software that comes with an easy 3-step process.You can see the preview before retrieving the data.Capable of recovering data from iCloud backup and iTunes backup.Recover data from all iOS versions and devices.For free technical support, you can also buy its Professional version at $59.95.Ĭompatibility: Compatible with both macOS and Windows. 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Is the software able to retrieve the data fast and securely? How much data can software recover? Can you save the recovered data? These are some of the critical considerations you must count on before finalizing the best software. ![]() Especially if you are an amateur user, you should consider the user interface as a significant consideration to avoid any confusion while running the program. The software you choose must have an intuitive interface to ease you with recovery. Hence, there are several factors one should consider before buying a free iPhone Data Recovery Software: Not all software ensures secure recovery of data. Free iPhone Data Recovery Software Selection Criteria Using this software, there are different types of data that you can recover from your iPhone, including photos, videos, contacts, messages, call history, WhatsApp chats, and more. This article will list some of the best free iPhone data recovery software on Mac and Windows. Whatever the reason, there are several different ways to recover data from your iPhone. ![]() ![]() Maybe you accidentally deleted an important file, or your phone has been damaged, and you need to retrieve any information. There are many reasons you might need to recover data from your iPhone. 6 Best Free iPhone Data Recovery Software for Mac & Windows Just select the best one for you from this list. What to do now? Don't Worry Here, we shortlisted the 6 best free iPhone data recovery software for Mac & Windows, with the pros and cons of each software. But it will become a nightmare when you accidentally delete your data, or your iPhones get damaged. You can keep all your essential data on your iOS device. ![]() Maybe your iPhone is the best storage device for you. ![]() |
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